Effector function of CTLs is increased by irradiated colorectal tumor cells that modulate OX-40L and 4-1BBL and is reversed following dual blockade
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چکیده
منابع مشابه
Radiation-induced modulation of immunogenic genes in tumor cells is regulated by both histone deacetylases and DNA methyltransferases.
Radiation treatment is a pivotal therapy for several cancer types, including colorectal cancer. It has been shown that sublethal doses of radiation modulate gene expression, making tumor cells more susceptible to T-cell-mediated immune attack. We have recently shown that low dose radiation enhances expression of multiple death receptors (Fas, DR4 and DR5) and co-stimulatory molecules (4-1BBL an...
متن کاملexpression of glucose transporter 4 (glut4) is increased by cinnamaldehyde in c2c12 mouse muscle cells
background: in diabetes mellitus because of the absence or insufficient sensitivity to insulin, glucose transporter protein in cell membrane, glucose transporter 4, is decreased. glut4 is the major glucose transporter in skeletal muscle and adipose tissue, which is under control of insulin. it remains, however, unclear whether cinnamaldehyde plays a regulatory role(s) or not. objectives: the ob...
متن کاملit is not possible to understand developments of a country’s culture and civilization without knowing his believes and myths. whether it is north or south, east or west, planes or mountains, sahara or deserts, here in iran every corner includes valuable and precious treasures which are known all over the world, and cultural – historical objects which are found here adorn all well known museums of the globe. zagros mountains, lorestan province locating at the heart of that, are not only the same, but are more prominent than other iranian regions. you can not find someone who does not know what the lorestani bronzes are, and there is no museum that not be pride of having a piece of that. the said bronzes which are manufactured four millenniums b.c. are admired nearly by all those researchers because of their beauty, diversity and technique. lorestani artistic works including stone engraves, bronzes and clays, show an ideal and metaphysical world beside real world which explain mental system of human beings on that era against sensations and phenomena happening around them. men main mental occupation on that time was he unknown world which had surrounded them, and they used to use the religion to fight life’s natural factors, and art was a tool of religious and mythical painting which was far from reality and had entered into the abstract domain. as natural objects have become subjects of lorestani art, it cleanses them from any non – intrinsic limitations and external factors which surround them and darken their meanings, and just shows their main specifications. artist in the said civilization is not searching for realism. although these are few works showing the nature, but in effect there is no wish to imitate touchable factors of the nature, and artist has turned real phenomena to encoded signs as per his own mentality. this procedure is called stylization.
it is not possible to understand developments of a country’s culture and civilization without knowing his believes and myths. whether it is north or south, east or west, planes or mountains, sahara or deserts, here in iran every corner includes valuable and precious treasures which are known all over the world, and cultural – historical objects which are found here adorn all well known museums...
Is Bax/Bcl-2 Ratio Considered as a Prognostic Marker with Age and Tumor Location in Colorectal Cancer?
Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. Therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. Methods: In this study, the relative level of mRNA expression of Bax and Bcl-2 genes was deter...
متن کاملTumor-infiltrating dendritic cells exhibit defective cross-presentation of tumor antigens, but is reversed by chemotherapy.
Cross-presentation defines the unique capacity of an APC to present exogenous Ag via MHC class I molecules to CD8(+) T cells. DCs are specialized cross-presenting cells and as such have a critical role in antitumor immunity. DCs are routinely found within the tumor microenvironment, but their capacity for endogenous or therapeutically enhanced cross-presentation is not well characterized. In th...
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ژورنال
عنوان ژورنال: BMC Research Notes
سال: 2016
ISSN: 1756-0500
DOI: 10.1186/s13104-016-1914-9